Article
The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes.
The Journal of biological chemistry - 24 Nov 1995
Gillespie-Brown J, Fuller S J, Bogoyevitch M A, Cowley S, Sugden P H
Abstract excerpt
Adult mammalian ventricular cardiomyocytes are terminally differentiated cells that enlarge adaptively by hypertrophy. In this situation, genes normally expressed in the fetal ventricular cardiomyocyte (e.g. atrial natriuretic factor (ANF), beta-myosin heavy chain (beta-MHC), and skeletal muscle...
Topics
- Amino Acid Sequence
- Animals
- Atrial Natriuretic Factor
- Calcium-Calmodulin-Dependent Protein Kinases
- Cardiomegaly
- Cells, Cultured
- Chickens
- Gene Expression
- Heart Ventricles
- Humans
- Luciferases
- MAP Kinase Kinase 1
- Mice
- Mitogen-Activated Protein Kinase 1