Article
Protein zero gene expression is regulated by the glial transcription factor Sox10.
Molecular and cellular biology - 1 May 2000
Peirano R I, Goerich D E, Riethmacher D, Wegner M
Abstract excerpt
Myelinating glia express high levels of a unique set of genes which code for structural proteins of the myelin sheath. Few transcription factors have so far been implicated in the regulation of any myelin gene. Here we show that the protein zero (P(0)) gene, a myelin gene exclusively expressed in the Schwann cell lineage of the peripheral nervous system, is controlled in its expression by the high-mobility-group...
Topics
- Animals
- Base Sequence
- Blotting, Western
- DNA-Binding Proteins
- Embryo, Mammalian
- Gene Expression Regulation
- High Mobility Group Proteins
- Humans
- In Situ Hybridization
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Myelin P0 Protein