Article
A clustering approach for localizing disease susceptibility loci.
Genetic epidemiology - 1 Jan 2001
Neuman R J, Bierut L J, Rasmussen E, Saccone N L, Rice J P, Corbett J, Sun L, Liu K Y
Abstract excerpt
Latent class (LCA) and cluster analysis (CLA) were utilized to identify trait loci for the Genetic Analysis Workshop 12 simulated disease. These techniques create non-overlapping subsets of concordant and discordant affected relative pairs based upon identity-by-descent (IBD) allele sharing at sequences of markers. Subgroups with a large proportion of affected pairs are used to identify markers in proximity to...
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