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Article

Parametric linkage analysis and disequilibrium methods to identify loci for complex disease.

Genetic epidemiology - 1 Jan 2001

McClintick J, Koller D L, Pankratz N, Kirkwood S C, Naughton B, Foroud T

Abstract excerpt

A two-step process was used to find loci contributing to the qualitative disease phenotype in the Genetic Analysis Workshop (GAW) 12 simulated data. The first step used parametric linkage analysis with a limited number of dominant and recessive models to detect linkage to chromosomal regions. Subsequently, a subset of the simulated biallelic sequence polymorphisms was used for transmission/disequilibrium tests...

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PMID: 11793731
DOI: 10.1002/gepi.2001.21.s1.s528

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