Article
Subpopulation difference scanning: a strategy for exclusion mapping of susceptibility genes.
Journal of medical genetics - 1 Jul 2006
Salmela E, Taskinen O, Seppänen J K, Sistonen P, Daly M J, Lahermo P, Savontaus M-L, Kere J
Abstract excerpt
BACKGROUND: Association mapping is a common strategy for finding disease-related genes in complex disorders. Different association study designs exist, such as case-control studies or admixture mapping. METHODS: We propose a strategy, subpopulation difference scanning (SDS), to exclude large fractions of the genome as locations of genes for complex disorders. This strategy is applicable to genes explaining...
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