Article
Locating the genes underlying a simulated complex disease by discriminant analysis.
Genetic epidemiology - 1 Jan 2001
Li X, Rao S, Elston R C, Olson J M, Moser K L, Zhang T, Guo Z
Abstract excerpt
The purpose of this study was to propose and evaluate a novel multivariate approach for genetic mapping of complex binary human diseases. This approach uses the application of either of two methods of standard (stepwise) discriminant analysis to detect linkage based on the differential marker identity-by-descent distributions among the three affection groups of sib pairs (concordantly affected, discordant, and...
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