Article
Methods for multipoint disease mapping using linkage disequilibrium.
Genetic epidemiology - 1 Jan 2000
Rannala B, Slatkin M
Abstract excerpt
A disease-associated mutation arises on a single chromosome such that alleles at linked markers are initially in complete linkage disequilibrium (LD) with the mutation. LD can be used as a tool for high-resolution mapping of the position of a disease mutation relative to a set of linked marker loci. When more than two linked marker loci are considered, developing a maximum likelihood approach is a challenging...
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