Article
Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data.
Genetic epidemiology - 1 Jan 2001
Wilk J B, Volcjak J S, Myers R H, Maher N E, Knowlton B A, Heard-Costa N L, Demissie S, Cupples L A, DeStefano A L
Abstract excerpt
Using the Genetic Analysis Workshop 12 simulated data, we contrasted results for association tests in nuclear families and extended pedigrees using single-nucleotide polymorphism (SNP) data, and we compared results for different trait definitions, for outbred and isolate populations, and for SNP and microsatellite data. SNPs in major genes 1 and 6 were analyzed using transmission disequilibrium testing (TDT)...
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