Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data.

doi:10.1002/gepi.2001.21.s1.s364

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Article

Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data.

Genetic epidemiology - 1 Jan 2001

Wilk J B, Volcjak J S, Myers R H, Maher N E, Knowlton B A, Heard-Costa N L, Demissie S, Cupples L A, DeStefano A L

Abstract excerpt

Using the Genetic Analysis Workshop 12 simulated data, we contrasted results for association tests in nuclear families and extended pedigrees using single-nucleotide polymorphism (SNP) data, and we compared results for different trait definitions, for outbred and isolate populations, and for SNP and microsatellite data. SNPs in major genes 1 and 6 were analyzed using transmission disequilibrium testing (TDT)...

Topics

Adult
Child
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 6
Female
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lod Score

Male

Microsatellite Repeats

Models, Genetic

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

Source

Open in PubMed

Identifiers

PMID: 11793700
DOI: 10.1002/gepi.2001.21.s1.s364

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