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Article

Comparison of novel and existing methods for detection of linkage disequilibrium using parent-child trios in the GAW12 genetic isolate simulated data.

Genetic epidemiology - 1 Jan 2001

Bailey-Wilson J E, Sorant A J, Malley J D, Presciuttini S, Redner R A, Severini T A, Badner J A, Pajevic S, Jufer R, Baffoe-Bonnie A, Kao L, Doan B Q, Goldstein J L, Holmes T N, Behneman D, Mandal D M, Turley T N, Weissbecker K A, O'Neill J, Pugh E W

Abstract excerpt

A novel method for joint detection of association caused by linkage disequilibrium (LD) and estimation of both recombination fraction and linkage disequilibrium parameters was compared to several existing implementations of the transmission/disequilibrium test (TDT) and modifications of the TDT in the simulated genetic isolate data from Genetic Analysis Workshop 12. The first completely genotyped trio of affected...

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PMID: 11793703
DOI: 10.1002/gepi.2001.21.s1.s378

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