Article
Using single nucleotide polymorphisms to investigate association between a candidate gene and disease.
Genetic epidemiology - 1 Jan 2001
Saunders C L, Crockford G P, Bishop D T, Barrett J H
Abstract excerpt
A range of study designs, using unrelated or family controls, were used to investigate the pattern of association with disease of single nucleotide polymorphisms (SNPs) within candidate gene 1 (simulated data). Strong evidence of disease association at the functional locus was detected using all study designs, and in the "general" but not the "isolated" population the functional polymorphism displayed...
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