Article

Disrupted Transcriptional Networks by Mutant Atrophin-1 in a Cell Culture Model of Dentatorubral-Pallidoluysian Atrophy

2025-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Dentatorubral-Pallidoluysian Atrophy (DRPLA) is a dominant neurodegenerative disease caused by CAG triplet repeat expansion in ATN1 , which encodes the transcriptional co-repressor Atrophin-1. DRPLA features motor, cognitive, and epileptic symptoms and shares pathogenic mechanisms with other polyglutamine (polyQ) disorders, including protein misfolding, impaired autophagy, and transcriptional d...

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Literature Corpus work: cd504e41-5ee4-5cfd-b3cf-7aaf61e6bd27
DOI: 10.1101/2025.08.08.669318

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