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Article

C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2009

Yu Juehua, Ying Mingyao, Zhuang Yuan, Xu Tian, Han Min, Wu Xiaohui, Xu Rener

Abstract excerpt

Dentatorubral-pallidoluysian atrophy (DRPLA) is a dominant hereditary neurodegenerative disorder caused by the expansion of a poly-glutamine (poly-Q) repeat in Atrophin-1 protein. Ectopic expression of a poly-Q expanded human Atrophin-1 is sufficient to induce DRPLA phenotypes in mice. However, it is still unclear whether the dominant effect of poly-Q expansion is due to the functional interference with wild-type...

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PMID: 19681162
DOI: 10.1002/dvdy.22063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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