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Article

Restrictions on components of variance for epistatic models.

Theoretical population biology - 1 Oct 1998

Tiwari H K, Elston R C

Abstract excerpt

If a disease is caused by several loci, then the additive variance at each locus may represent only small portions of the total genetic variance, while epistatic variance components may explain a significant amount of the total genetic variance. In this paper we first give simple general formulations to derive all the components of total genetic variance in a random sample for any multilocus model. We then derive...

Topics

Epistasis, Genetic
Gene Frequency
Genetic Diseases, Inborn
Genetic Linkage
Genetic Variation
Humans
Models, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9733657
DOI: 10.1006/tpbi.1997.1373

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