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Article

Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death.

Current biology : CB - 18 Nov 1999

Ahlgren S C, Bronner-Fraser M

Abstract excerpt

BACKGROUND: Sonic hedgehog (Shh) is well known for its role in patterning tissues, including structures of the head. Haploinsufficiency for SHH in humans results in holoprosencephaly, a syndrome characterized by facial and forebrain abnormalities. Shh null mice have cyclopia and loss of branchial arch structures. It is unclear, however, whether these phenotypes arise solely from the early function of Shh in...

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Source

Identifiers

PMID: 10574760
DOI: 10.1016/s0960-9822(00)80052-4

Genes

SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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