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Article

Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010

Huang Xi, Liu Jiang, Ketova Tatiana, Fleming Jonathan T, Grover Vandana K, Cooper Michael K, Litingtung Ying, Chiang Chin

Abstract excerpt

Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain elusive. We reveal that Sonic hedgehog (Shh) signaling is active in the cerebellar VZ and essential to radial glial cell proliferation and expansion of GABAergic interneurons. We demonstrate that the cerebellum...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20400693
DOI: 10.1073/pnas.0911838107
PMCID: PMC2889567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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