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Article

Prevalence of CTLA-4 polymorphism A49G in Ashkenazi Jews.

Genetic testing - 1 Jan 2001

Mack R, Chowdary D, Samaan P, Podolak I, Dermody J

Abstract excerpt

Type 1 diabetes has been associated with numerous genetic loci. One locus, IDD12, includes the gene for cytotoxic T lymphocyte antigen (CTLA-4). A polymorphism at position 49 in the CTLA-4 gene, causing a substitution of Thr --> Ala, has been associated with various autoimmune diseases, including diabetes. The frequency of the polymorphism in European and Oriental populations has been recorded, but the frequency...

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PMID: 11788096
DOI: 10.1089/10906570152742353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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