Article
Association of the M3151 variant in the transient receptor potential vanilloid receptor-1 (TRPV1) gene with type 1 diabetes in an Ashkenazi Jewish population.
The Israel Medical Association journal : IMAJ - 1 Sept 2013
Sadeh Menachem, Glazer Benjamin, Landau Zohar, Wainstein Julio, Bezaleli Tall, Dabby Ron, Hanukoglu Aaron, Boaz Mona, Leshinsky-Silver Esther
Abstract excerpt
BACKGROUND: Type 1 diabetes in humans is an autoimmune disease in which Tcells target pancreatic islets of Langerhans, leading to the progressive destruction of the insulin-producing beta cells. Both genetic and environmental factors contribute to the development of autoimmune diabetes. The non-obese diabetic (NOD) mouse model of human type 1 diabetes demonstrates two missense mutations in the transient receptor...
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