Article
Mutations in the pfmdr1, cg2, and pfcrt genes in Plasmodium falciparum samples from endemic malaria areas in Rondonia and Pará State, Brazilian Amazon Region.
Cadernos de saude publica - 1 Dec 2006
Viana Giselle Maria Rachid, Machado Ricardo Luís Dantas, Calvosa Vanja Sueli Pachiano, Póvoa Marinete Marins
Abstract excerpt
The objectives of this study were to investigate the molecular basis for Plasmodium falciparum resistance to chloroquine in isolates from the Brazilian Amazon and to identify polymorphisms in the pfmdr1 gene, codons 184, 1042, and 1246, the kappa and gamma regions of the cg2 gene, and the K76T mu...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antimalarials
- Brazil
- Chloroquine
- Codon
- Drug Resistance
- Genetic Markers
- Humans
- Membrane Transport Proteins
- Mutation
- Plasmodium falciparum
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Protozoan Proteins