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Article

Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1.

Oncogene - 13 Dec 2001

Fan S, Yuan R, Ma Y X, Meng Q, Goldberg I D, Rosen E M

Abstract excerpt

Unregulated expression of wild-type BRCA1 (wtBRCA1) confers an altered phenotype in cultured human prostate cancer cells, characterized by chemosensitivity, susceptibility to apoptosis, decreased DNA repair activity, and alterations of key cell regulatory proteins. We now report that the expression of truncated or mutant full-length BRCA1 genes can abrogate certain phenotypic characteristics and/or confer the...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Genes, BRCA1

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Source

Identifiers

PMID: 11781837
DOI: 10.1038/sj.onc.1205033

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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