Article
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Oncogene - 4 Jan 2001
Fan S, Ma Y X, Wang C, Yuan R Q, Meng Q, Wang J A, Erdos M, Goldberg I D, Webb P, Kushner P J, Pestell R G, Rosen E M
Abstract excerpt
The BRCA1 gene was previously found to inhibit the transcriptional activity of the estrogen receptor [ER-alpha] in human breast and prostate cancer cell lines. In this study, we found that breast cancer-associated mutations of BRCA1 abolish or reduce its ability to inhibit ER-alpha activity and that domains within the amino- and carboxyl-termini of the BRCA1 protein are required for the inhibition. BRCA1...
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