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BRCA1 Inhibition of Telomerase Activity in Cultured Cells

12 Nov 2003

Abstract excerpt

Telomerase, an enzyme that maintains telomere length, plays major roles in cellular immortalization and cancer progression. We found that an exogenous BRCA1 gene strongly inhibited telomerase enzymatic activity in human prostate and breast cancer cell lines and caused telomere shortening in cell lines expressing wild-type BRCA1 (wtBRCA1) but not a tumor-associated mutant BRCA1 (T300G). wtBRCA1 inhibited the...

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PMID: 14612409
DOI: 10.1128/mcb.23.23.8668-8690.2003

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