Article
Protein-protein communication: structural model of the repression complex formed by CytR and the global regulator CRP.
Cell - 27 Jun 1997
Kallipolitis B H, Nørregaard-Madsen M, Valentin-Hansen P
Abstract excerpt
The cAMP receptor protein (CRP) and the LacI-related CytR antiactivator bind cooperatively to adjacent DNA sites at or near promoters, an interaction that involves direct protein contacts. Here, we identify a collection of amino acid substitutions in CytR that reestablish protein-protein communication to mutant CRP proteins specifically defective in cooperative binding with wild-type CytR. To assess the location...
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