Article
A single P115Q mutation modulates specificity in the Corynebacterium pseudotuberculosis arginine repressor.
Biochimica et biophysica acta. General subjects - 1 Jul 2020
Mariutti Ricardo B, Hernández-González Jorge E, Nascimento Andrey F Z, de Morais Mariana A B, Murakami Mario T, Carareto Claudia M A, Arni Raghuvir K
Abstract excerpt
The arginine repressor (ArgR) regulates the expression of genes involved in arginine biosynthesis. Upon attaining a threshold concentration of arginine in the cytoplasm, the trimeric C-terminal domain of ArgR binds three arginines in a shallow surface cleft and subsequently hexamerizes forming a dimer of trimers containing six Arg co-repressor molecules which are buried at the subunit interfaces. The N-terminal...
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