Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation.

The Journal of biological chemistry - 13 Jun 2003

Jiang Ning, Bénard Claire Y, Kébir Hania, Shoubridge Eric A, Hekimi Siegfried

Abstract excerpt

Mutations in the clk-2 gene of the nematode Caenorhabditis elegans affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length. clk-2 encodes a novel protein (CLK-2) with a unique homologue in each of the sequenced eukaryotic genomes. We have studied the human homologue of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to Immunoblotting
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

Share to Protein-Tyrosine Kinases

Share to RNA, Small Interfering

Share to Subcellular Fractions

Share to Telomere

Source

Identifiers

PMID: 12670948
DOI: 10.1074/jbc.M300286200

Genes

CLK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation.PMID 12670948Read ↗

C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p.Semantic proximity Read ↗

Functional Dissection of Caenorhabditis elegans CLK-2/TEL2 Cell Cycle Defects during Embryogenesis and Germline DevelopmentSemantic proximity Read ↗

The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length.Semantic proximity Read ↗

Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging.Semantic proximity Read ↗

Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrestSemantic proximity Read ↗

The Chk2 protein kinase.Semantic proximity Read ↗

The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2.Semantic proximity Read ↗

Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.Semantic proximity Read ↗

Missing women—revisitedSemantic proximity Read ↗

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein.Semantic proximity Read ↗

Comparison of the CDC2-like kinase family across eukaryotes highlights the functional conservation of these unique biological thermometersSemantic proximity Read ↗

CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.