Replacement of N-terminal portions of TGF-alpha with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins.

Abstract excerpt

ErbB receptor tyrosine kinases play an important role in developmental processes and tumor formation. Their activity is regulated by a family of structurally related ligands that bind to distinct ErbB receptor subsets, with transforming growth factor (TGF)-alpha preferentially interacting with epidermal growth-factor receptor (EGFR) and heregulin (HRG)-beta1 recognizing ErbB3 and ErbB4. To investigate the...

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