Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A lysine-free mutant of epidermal growth factor as targeting moiety of a targeted toxin.

Life sciences - 31 Jan 2011

Bachran Christopher, Schneider Stefanie, Riese Sebastian B, Bachran Diana, Urban Romy, Schellmann Nicole, Zahn Claudia, Sutherland Mark, Fuchs Hendrik

Abstract excerpt

AIMS: Elevated levels of epidermal growth factor (EGF) receptor are observed on several human tumors, e.g. cervical carcinoma and mamma carcinomas. The natural ligand EGF is an alternative to established antibodies and tyrosine kinase inhibitors for targeting EGF receptor-overexpressing tumor cel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Drug Delivery Systems
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotoxins

Share to Lysine

Share to NIH 3T3 Cells

Share to Protein Binding

Source

Identifiers

PMID: 21094170
DOI: 10.1016/j.lfs.2010.11.012

Genes

EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21094170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A lysine-free mutant of epidermal growth factor as targeting moiety of a targeted toxin.PMID 21094170Read ↗

Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery.Semantic proximity Read ↗

Isolation from phage display libraries of lysine-deficient human epidermal growth factor variants for directional conjugation as targeting ligands.Semantic proximity Read ↗

Development of a human epidermal growth factor derivative with EGFR-blocking and depleted biological activities: A comparative in vitro study using EGFR-positive breast cancer cells.Semantic proximity Read ↗

A new scfv-based recombinant immunotoxin against EPHA2-overexpressing breast cancer cells; High in vitro anti-cancer potency.Semantic proximity Read ↗

Replacement of N-terminal portions of TGF-alpha with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins.Semantic proximity Read ↗

Functional expression of a single-chain antibody to ErbB-2 in plants and cell-free systemsSemantic proximity Read ↗

An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin.Semantic proximity Read ↗

c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes.Semantic proximity Read ↗

An albumin‑binding domain and targeting peptide‑based recombinant protein and its enediyne‑integrated analogue exhibit directional delivery and potent inhibitory activity on pancreatic cancer with K‑ras mutation.Semantic proximity Read ↗

A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity.Semantic proximity Read ↗

Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.Semantic proximity Read ↗

Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.