Article
Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Heimbrook D C, Stirdivant S M, Ahern J D, Balishin N L, Patrick D R, Edwards G M, Defeo-Jones D, FitzGerald D J, Pastan I, Oliff A
Abstract excerpt
Transforming growth factor alpha (TGF alpha)-Pseudomonas exotoxin 40 (PE40) is a chimeric protein consisting of an N-terminal TGF alpha domain fused to a C-terminal 40-kDa segment of the Pseudomonas exotoxin A protein. TGF alpha-PE40 exhibits the receptor-binding activity of TGF alpha and the cell-killing activity of PE40. These properties make TGF alpha-PE40 an effective cytotoxic agent for cells that possess...
Topics
- ADP Ribose Transferases
- Alanine
- Animals
- Antineoplastic Agents
- Bacterial Toxins
- Cell Line
- Cloning, Molecular
- Cysteine
- ErbB Receptors
- Exotoxins