Article
Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein.
Cancer research - 1 Aug 1998
Seetharam S, Nodzenski E, Beckett M A, Heimann R, Cha A, Margulies I, Pastan I, Kufe D W, Weichselbaum R R
Abstract excerpt
Strategies to sensitize human tumors that are resistant to apoptosis have been clinically unsuccessful. We demonstrate that a structurally modified chimeric Pseudomonas exotoxin, PEdelta53L/TGF-alpha/KDEL, with binding specificity for the epidermal growth factor receptor, markedly enhances sensit...
Topics
- ADP Ribose Transferases
- Animals
- Apoptosis
- Bacterial Toxins
- Binding Sites
- Carcinoma, Squamous Cell
- Ceramides
- Combined Modality Therapy
- Drug Synergism
- ErbB Receptors
- Exotoxins
- Female
- Head and Neck Neoplasms
- Humans
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation