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Article

Identification of Heregulin, a Specific Activator of p185 <sup>erbB2</sup>

22 May 1992

Abstract excerpt

The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. Several complementary DNA...

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PMID: 1350381
DOI: 10.1126/science.256.5060.1205

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Identification of Heregulin, a Specific Activator of p185 <sup>erbB2</sup>PMID 1350381Read ↗

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