Article
Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates.
The Journal of biological chemistry - 22 Mar 2002
Koike Chihiro, Fung John J, Geller David A, Kannagi Reiji, Libert Therese, Luppi Patrizia, Nakashima Izumi, Profozich Jennifer, Rudert William, Sharma Sugandha B, Starzl Thomas E, Trucco Massimo
Abstract excerpt
Galactose-alpha1,3-galactose (alphaGal) epitopes, the synthesis of which requires the enzyme product of alpha1,3-galactosyltransferase (alpha1,3GT), are sugar chains on the cell surface of most mammalian species. Notable exceptions are higher primates including Old World monkeys, apes, and humans. The alphaGal-negative species as well as mice with deletion of the alpha1,3GT gene produce abundant anti-alphaGal...
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