Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.

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Article

Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.

The Journal of biological chemistry - 25 Feb 1992

Weston B W, Nair R P, Larsen R D, Lowe J B

Abstract excerpt

Biochemical and genetic evidence indicates that the human genome may encode four or more distinct GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (alpha(1,3)fucosyltransferase) activities. Genes encoding two of these activities have been previously isolated. These correspond to an alpha(1,3/1,4)fucosyltransferase thought to represent the human Lewis blood group locus and an...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cell Line, Transformed
Chromosome Mapping
Cloning, Molecular
DNA
Electrophoresis, Polyacrylamide Gel
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fucosyltransferases

Gene Expression

Humans

Molecular Sequence Data

Polymerase Chain Reaction

Sequence Homology, Nucleic Acid

Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 1740457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1740457-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.PMID 1740457Read ↗

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