Article
Osteoblasts are target cells for transformation in c-fos transgenic mice.
The Journal of cell biology - 1 Aug 1993
Grigoriadis A E, Schellander K, Wang Z Q, Wagner E F
Abstract excerpt
We have generated transgenic mice expressing the proto-oncogene c-fos from an H-2Kb class I MHC promoter as a tool to identify and isolate cell populations which are sensitive to altered levels of Fos protein. All homozygous H2-c-fosLTR mice develop osteosarcomas with a short latency period. This...
Topics
- Animals
- Base Sequence
- Bone Neoplasms
- Calcitriol
- Cell Transformation, Neoplastic
- Dexamethasone
- Gene Expression
- Genes, fos
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Osteoblasts
- Osteogenesis
- Osteosarcoma
- Phenotype
- Proto-Oncogene Proteins c-fos
- Tumor Cells, Cultured