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Article

Osteoblasts are target cells for transformation in c-fos transgenic mice.

The Journal of cell biology - 1 Aug 1993

Grigoriadis A E, Schellander K, Wang Z Q, Wagner E F

Abstract excerpt

We have generated transgenic mice expressing the proto-oncogene c-fos from an H-2Kb class I MHC promoter as a tool to identify and isolate cell populations which are sensitive to altered levels of Fos protein. All homozygous H2-c-fosLTR mice develop osteosarcomas with a short latency period. This phenotype is specific for c-fos as transgenic mice expressing the fos- and jun-related genes, fosB and c-jun, from the...

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Identifiers

PMID: 8335693
DOI: 10.1083/jcb.122.3.685
PMCID: PMC2119671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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