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Article

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002

Barak Yaacov, Liao Debbie, He Weimin, Ong Estelita S, Nelson Michael C, Olefsky Jerrold M, Boland Richard, Evans Ronald M

Abstract excerpt

Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor delta (PPARdelta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPARdelta(-/-) mice exhibit a striking reduction in adiposity relative to wild-type levels. This effect is not reproduced in mice harboring an adipose tissue-specific deletion of PPARdelta, and...

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Identifiers

PMID: 11756685
DOI: 10.1073/pnas.012610299
PMCID: PMC117556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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