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Article

Natural helix 9 mutants of PPARγ differently affect its transcriptional activity

15 Dec 2018

Abstract excerpt

OBJECTIVE: The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-function mutations in PPARG result in familial partial lipodystrophy subtype 3 (FPDL3), a rare condition characterized by aberrant adipose tissue distribution and severe...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 30595551
DOI: 10.1016/j.molmet.2018.12.005

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