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Article

Genetic disruption of <i>PPAR</i> δ decreases the tumorigenicity of human colon cancer cells

27 Feb 2001

Abstract excerpt

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPARdelta isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC)/beta-catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPARdelta null cell line was created by targeted homologous...

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PMID: 11226285
DOI: 10.1073/pnas.051630998

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