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Article

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

14 Feb 2025

Abstract excerpt

Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear. Here, it is reported that the placentas of women with pregnancies complicated with FGR exhibit peroxisome proliferator-activated receptor γ (PPARγ) inactivation. In mice, trophoblast-specific ablation of murine PPARγ reproduces the phenotype of human...

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Identifiers

PMID: 39951006
DOI: 10.1002/advs.202404983

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The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγPMID 39951006Read ↗

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