Article
APOE-epsilon4 and APOE -491A polymorphisms in individuals with subjective memory loss.
Molecular psychiatry - 1 Jan 2002
Laws S M, Clarnette R M, Taddei K, Martins G, Paton A, Hallmayer J, Almeida O P, Groth D M, Gandy S E, Förstl H, Martins R N
Abstract excerpt
The accurate clinical diagnosis of Alzheimer's disease can only be made with a high degree of certainty in specialized centres. The identification of predictive or diagnostic genetic factors may improve accuracy of disease prediction or diagnosis. One major genetic risk factor, the epsilon4 allele of the apolipoprotein E gene, is universally recognised. We have recently shown that the A allele of the...
Topics
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Genetic Predisposition to Disease
- Genotype
- Humans
- Memory Disorders
- Polymorphism, Genetic
- Predictive Value of Tests
- Promoter Regions, Genetic