ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.

doi:10.1038/s41375-019-0618-2

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Article

ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.

Leukemia - 1 Mar 2020

Riabinska Arina, Lehrmann Daria, Jachimowicz Ron Daniel, Knittel Gero, Fritz Christian, Schmitt Anna, Geyer Aenne, Heneweer Carola, Wittersheim Maike, Frenzel Lukas P, Torgovnick Alessandro, Wiederstein Janica Lea, Wunderlich Claudia Maria, Ortmann Monika, Paillard Arlette, Wößmann Wilhelm, Borkhardt Arndt, Burdach Stefan, Hansmann Martin-Leo, Rosenwald Andreas, Perner Sven, Mall Gita, Klapper Wolfram, Merseburg Andrea, Krüger Marcus, Grüll Holger, Persigehl Thorsten, Wunderlich Frank Thomas, Peifer Martin, Utermöhlen Olaf, Büttner Reinhard, Beleggia Filippo, Reinhardt Hans Christian

Abstract excerpt

The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer predisposition. Whether ATM deficiency impacts on tumor initiation or also on the maintenance of the malignant state is unclear. Here, we show that Atm reactivation in initially Atm-deficient B- and T cell...

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PMID: 31690822
DOI: 10.1038/s41375-019-0618-2

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