Article
Molecular perspectives on cancer, the cell cycle and the inherited disorder ataxia-telangiectasia.
Progress in clinical and biological research - 1 Jan 1997
Brown K D, Tagle D A
Abstract excerpt
Ataxia-Telangiectasia (A-T) is an autosomal recessive disorder which presents a wide array of clinical symptoms including enhanced cancer predisposition and progressive cerebellar degeneration leading to general neuromotor dysfunction. The A-T cellular phenotype consists of higher levels of chromosome breakage, increased sensitivity to ionizing radiation and radiomimetic drugs, and defective cell cycle...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.