Article
Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria.
Blood - 1 Jan 2002
Horikawa Kentaro, Kawaguchi Tatsuya, Ishihara Sonoko, Nagakura Shoichi, Hidaka Michihiro, Kagimoto Tadashi, Mitsuya Hiroaki, Nakakuma Hideki
Abstract excerpt
Acquired mutations of the PIG-A gene result in the hemolysis characteristic of paroxysmal nocturnal hemoglobinuria (PNH). Although the etiology of the mutation(s) is unclear, mutable conditions have been suggested by the coexistence of multiple clones with different mutations of PIG-A and by the appearance of leukemic clones in patients with PNH. This study sought to test this hypothesis by examining the...
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