New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria.

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Article

New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria.

Blood - 1 Nov 1998

Nafa K, Bessler M, Deeg H J, Luzzatto L

Abstract excerpt

We report a detailed longitudinal study of the first patient to be treated (in 1973) for paroxysmal nocturnal hemoglobinuria (PNH) with syngeneic bone marrow transplantation (BMT). The patient subsequently relapsed with PNH in 1983, and still has PNH to date. Analysis of the PIG-A gene in a recen...

Topics

Adolescent
Base Sequence
Bone Marrow Transplantation
Clone Cells
DNA Mutational Analysis
Diseases in Twins
Exons
Gene Duplication
Graft Survival
Hematopoietic Stem Cells
Hemoglobinuria, Paroxysmal
Humans
Male
Membrane Proteins
Mutagenesis, Insertional
Mutation
Polymerase Chain Reaction
Recurrence

Source

Open in PubMed

Identifiers

PMID: 9787183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9787183-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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