Clinical and molecular aspects of 23 patients affected by paroxysmal nocturnal hemoglobinuria.

doi:10.1002/ajh.20144

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Article

Clinical and molecular aspects of 23 patients affected by paroxysmal nocturnal hemoglobinuria.

American journal of hematology - 1 Sept 2004

Boschetti Carla, Fermo Elisa, Bianchi Paola, Vercellati Cristina, Barraco Fiorenza, Zanella Alberto

Abstract excerpt

We reviewed clinical and molecular data of 23 consecutive unrelated patients affected by paroxysmal nocturnal hemoglobinuria (PNH) (19 with hemolytic PNH, 3 with aplastic anemia/PNH, and 1 with myelodysplasia/PNH syndrome) with a mean follow-up of 11.8 years. Five patients had thrombotic episodes, and 10 needed regular blood transfusions; 2 died for cerebral hemorrhage and kidney failure, and 2 spontaneously...

Topics

Adolescent
Adult
Antilymphocyte Serum
Cyclosporine
DNA Mutational Analysis
Drug Monitoring
Erythropoietin
Female
Follow-Up Studies
Hemoglobins
Hemoglobinuria, Paroxysmal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunosuppression Therapy

Male

Membrane Proteins

Middle Aged

Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 15307104
DOI: 10.1002/ajh.20144

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