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Article

Genetic instability and the etiology of somatic PIG-A mutations in paroxysmal nocturnal hemoglobinuria.

Blood cells, molecules & diseases - 1 Apr 1999

Purow D B, Howard T A, Marcus S J, Rosse W F, Ware R E

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is a hematologic disorder characterized by acquired PIG-A gene mutations that lead to defective bioassembly of glycosylphosphatidylinositol (GPI) anchors and the absence of GPI-linked surface proteins. As the etiology of these acquired PIG-A gene mutations is unknown, we hypothesized that patients with PNH have overall genetic instability and acquire somatic mutations...

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Share to Gene Rearrangement, T-Lymphocyte
Share to Hemoglobinuria, Paroxysmal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxanthine Phosphoribosyltransferase

Share to Immunoglobulin Joining Region

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

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Source

Identifiers

PMID: 10389589
DOI: 10.1006/bcmd.1999.0229

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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