Article
On the validity of the TDT test in the presence of comorbidity and ascertainment bias.
Genetic epidemiology - 1 Dec 2001
Robins J M, Smoller J W, Lunetta K L
Abstract excerpt
Comorbidity, the association of two disorders, occurs commonly with complex diseases. In this paper, we investigate the effects of both true (within-family) comorbidity and spurious comorbidity due to ascertainment bias on the validity of both the parental and sibling control transmission/disequilibrium test. Specifically, we consider settings in which a candidate gene is unlinked to the target phenotype but is...
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