Article
Predominance of sterile immunoglobulin transcripts in a female phenotypically resembling Bruton's agammaglobulinemia.
European journal of immunology - 1 Mar 1995
de la Morena M, Haire R N, Ohta Y, Nelson R P, Litman R T, Day N K, Good R A, Litman G W
Abstract excerpt
The transcription pattern of the heavy chain immunoglobulin gene locus was analyzed in a 6-month-old female with agammaglobulinemia characterized by the absence of mature B cells in peripheral blood, arrested B cell development in the bone marrow and lack of germinal center development. DNA seque...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- B-Lymphocytes
- Base Sequence
- Cell Line
- Cloning, Molecular
- Female
- Gene Library
- Humans
- Immunoglobulins
- Infant
- Molecular Sequence Data
- Phenotype
- Protein-Tyrosine Kinases
- RNA, Messenger
- Transcription, Genetic