Article
Predominance of sterile immunoglobulin transcripts in a female phenotypically resembling Bruton's agammaglobulinemia.
European journal of immunology - 1 Mar 1995
de la Morena M, Haire R N, Ohta Y, Nelson R P, Litman R T, Day N K, Good R A, Litman G W
Abstract excerpt
The transcription pattern of the heavy chain immunoglobulin gene locus was analyzed in a 6-month-old female with agammaglobulinemia characterized by the absence of mature B cells in peripheral blood, arrested B cell development in the bone marrow and lack of germinal center development. DNA sequencing provided no evidence of mutations within the coding region of the Bruton's tyrosine kinase gene. Polymerase chain...
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