Article
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.
Journal of endotoxin research - 1 Jan 2001
Bernheiden M, Heinrich J M, Minigo G, Schütt C, Stelter F, Freeman M, Golenbock D, Jack R S
Abstract excerpt
In mice, defense against an intraperitoneal Salmonella infection depends on a vigorous innate immune response. Mutations which lead to an inadequate early response to the pathogen thus identify genes involved in innate immunity. The best studied host resistance factor, NRAMP-1, is an endosomal membrane protein whose loss leads to an inability of the animals to hold the infection in check. However, innate defense...
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