Article
Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.
PloS one - 1 Jan 2014
Loomis Wendy P, Johnson Matthew L, Brasfield Alicia, Blanc Marie-Pierre, Yi Jaehun, Miller Samuel I, Cookson Brad T, Hajjar Adeline M
Abstract excerpt
The lysosomal membrane transporter, Nramp1, plays a key role in innate immunity and resistance to infection with intracellular pathogens such as non-typhoidal Salmonella (NTS). NTS-susceptible C57BL/6 (B6) mice, which express the mutant Nramp1D169 allele, are unable to control acute infection with Salmonella enterica serovar Typhimurium following intraperitoneal or oral inoculation. Introducing functional...
Topics
- Alleles
- Animals
- Body Weight
- Cation Transport Proteins
- Chromosomes
- Genotype
- Homozygote
- Immunity, Innate
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- Polymorphism, Single Nucleotide