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Article

Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.

PloS one - 1 Jan 2014

Loomis Wendy P, Johnson Matthew L, Brasfield Alicia, Blanc Marie-Pierre, Yi Jaehun, Miller Samuel I, Cookson Brad T, Hajjar Adeline M

Abstract excerpt

The lysosomal membrane transporter, Nramp1, plays a key role in innate immunity and resistance to infection with intracellular pathogens such as non-typhoidal Salmonella (NTS). NTS-susceptible C57BL/6 (B6) mice, which express the mutant Nramp1D169 allele, are unable to control acute infection with Salmonella enterica serovar Typhimurium following intraperitoneal or oral inoculation. Introducing functional...

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Identifiers

PMID: 25350459
DOI: 10.1371/journal.pone.0111763
PMCID: PMC4211889

Genes

NTS
MLN

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Source receipt: pubmed, retrieved 7 Sept 2026.

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