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Article

The crucial role of polymorphonuclear leukocytes in resistance to Salmonella dublin infections in genetically susceptible and resistant mice.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998

Vassiloyanakopoulos A P, Okamoto S, Fierer J

Abstract excerpt

Macrophages are considered to be the mediators of resistance to extra-intestinal Salmonella infections. Nevertheless, the initial cellular response to Salmonella infections consists primarily of polymorphonuclear leukocytes (PMN). To determine whether PMN serve an important function for the infected host, we made mice neutropenic with the rat mAb to RB6-8C5 and infected them i.v. with approximately 10(3)...

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Identifiers

PMID: 9636209
DOI: 10.1073/pnas.95.13.7676
PMCID: PMC22720

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