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Article

The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2002

Fierer Joshua, Swancutt Mark A, Heumann Didier, Golenbock Douglas

Abstract excerpt

Polymorphonuclear leukocytes (PMN) and LPS-binding protein (LBP) are both components of the innate immune system. LBP is a plasma protein that binds to lipid A and enhances the biological activity of LPS 100- to 1000-fold. Recently it was reported that LBP-deficient mice are more susceptible to Salmonella typhimurium infection. Here we report that LBP KO mice are more susceptible to Salmonella peritonitis, but...

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Source

Identifiers

PMID: 12055258
DOI: 10.4049/jimmunol.168.12.6396

Genes

LBP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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