Article
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Molecular pharmacology - 1 Jan 2002
Cooper Roland A, Ferdig Michael T, Su Xin-Zhuan, Ursos Lyann M B, Mu Jianbing, Nomura Takashi, Fujioka Hisashi, Fidock David A, Roepe Paul D, Wellems Thomas E
Abstract excerpt
Chloroquine resistance (CQR) in Plasmodium falciparum is associated with multiple mutations in the digestive vacuole membrane protein PfCRT. The chloroquine-sensitive (CQS) 106/1 line of P. falciparum has six of seven PfCRT mutations consistently found in CQR parasites from Asia and Africa. The missing mutation at position 76 (K76T in reported population surveys) may therefore be critical to CQR. To test this...
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